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Brand names in this class of drugs include Ozempic, Wegovy, Rybelsus, and Saxenda, manufactured by Novo Nordisk, and Mounjaro, Zepbound, and Trulicity, manufactured by Eli Lilly

Removal of the N-terminal 55 residues or ECD deletion completely abolished the activation effect of compound 2 despite that it binds to the cytoplasmic side of TM6, consistent with our previous report that ECD is required for GLP-1R and GCGR activation 34

Over time, GeneDx plans to expand into newborn screening, a potentially $10 billion marketthen eventually into adult screening to replace multi-gene panel and individual gene tests, a future market pegged at $16 billion, Katherine Stueland, GeneDxs president and CEO, told GEN Edge last month With tougher comps in 25 and a potential headwind to revenues emerging in HCT, it is harder to argue for multiple expansion from here, Peterson said